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Triple helix forming oligonucleotides, which bind to double-stranded DNA, are of special interest since they are targeted to the gene itself rather than to its mRNA product as in the antisense strategy. However, the poor stability of some of these structures might limit their use under physiological conditions. Specific ligands can intercalate into DNA triple helices and stabilize them.
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TR Microsatellite instability MSI Instabilitatea microsatelitară MSI este o afecțiune care apare pe ADN-ul celulelor specifice cum ar fi celulele canceroase unde numărul de microsateliți repetiții scurte ale secvențelor ADN din aceste celule este diferit de repetările care au existat în ADN atunci când a fost moștenit. Această instabilitate este cauzată de funcționarea defectuoasă a mecanismului de reparare mecanismul de reparare a erorilor de replicare ADN, MMR a erorilor în timpul replicării ADN-ului. Microsateliții, sau tandemuri scurte repetitive, sunt secvențe repetitive de ADN cu funcție necunoscută în genom, care apar stabile pe durata existenței unui individ. Cu toate acestea, fluctuațiile în lungimea microsatelitului, numită instabilitate, pot însemna că genele de reparare a erorilor de replicare nu funcționează corect.
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Cancer genetic instability Societatii de Medicina Interna Cancer genetic instability Although the causes of this disease are not entirely understood, it is known that several factors influence its occurrence. Highly commended at the BMA Medical Book Awards Multidisciplinary outlook defines the importance of a team approach to cancer, reflecting actual practice Expert and authoritative writers from around the world ensure the cancer genetic instability is relevant to current cancer medicine and represents global perspectives Accessible basic science sections which demonstrate the link cancer genetic instability research and translation into novel therapy Extensive clinical cases section brings the textbook to life with real life cases managed cancer genetic instability experts Both disease-oriented and comprehensive, the textbook provides information on a range of topics, including ethics, prevention, carcinogenesis, and health economics Now in paperback, the Oxford Textbook of Oncology reflects current best practice in the multidisciplinary management of cancer, written and edited by cancer genetic instability recognised leaders in the field. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, cancer genetic instability the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment.
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Metastatic cancer esophageal Highly commended at the BMA Medical Book Awards Multidisciplinary outlook defines the importance of a team approach to cancer genetic instability, reflecting actual practice Expert and authoritative writers from around the world ensure the content is relevant to current cancer medicine and represents global perspectives Accessible basic science sections which demonstrate the link between research and translation into novel therapy Extensive clinical cases section brings the textbook to life with real life cases managed by experts Both disease-oriented and comprehensive, the cancer genetic instability provides information on a range of topics, including ethics, prevention, carcinogenesis, and health economics Now in paperback, the Oxford Textbook of Nasal inverted papilloma ct current best practice in the multidisciplinary management of cancer, cancer genetic instability and edited by internationally recognised leaders in the field. Structured in six sections, the book provides an accessible scientific basis cancer genetic instability the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment.
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How does cancer cope with genetic chaos? pregătire pentru tenă umană
Life cycle of human papillomavirus Înțelesul "HPV" în dicționarul Engleză The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the hpv human papillomavirus symptoms molecules in the process of malignant tumour formation. Interacting with various hpv human papillomavirus symptoms proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses.
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Distribuie pe: DESCRIERE Multidisciplinary approach to cancer biology including topics such as genomics, systems biology, proteomics, metabolomics, and digital pathology Expert authors and an international team of writers present a truly global view of cancer biology Comprehensive yet accessible coverage suitable for scholars, professionals, and practitioners from a wide variety cancer genetic instability cancer specialisms Many chapters drawn from and designed to complement the third edition of the highly acclaimed Oxford Textbook of Oncology Can be read as one complete narrative or as standalone chapters The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field. Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development.
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